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tfan



Joined: 31 May 2010
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PostPosted: 05/18/20 11:23 pm    ::: Reply Reply with quote

DOUBTS OVER OXFORD COVID-19 VACCINE AFTER ANIMALS TESTED CATCH VIRUS

Quote:
Although all of the monkeys were found to have been infected with the virus, none suffered from pneumonia, which suggests the vaccine could help fight the severity of COVID-19, which may give optimism to some.




Last edited by tfan on 05/18/20 11:31 pm; edited 1 time in total
tfan



Joined: 31 May 2010
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PostPosted: 05/18/20 11:24 pm    ::: Reply Reply with quote

Russia hopes to start COVID-19 vaccine trials soon - health minister


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Russia, whose 290,678 confirmed infections is the second-highest number of coronavirus cases behind the United States, has been testing vaccine prototypes on animals.


tfan



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PostPosted: 05/20/20 3:19 am    ::: Reply Reply with quote

Coronavirus: European stocks fall as doubts grow over vaccine


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A report from the highly respected Stat News suggested that Massachusetts-based Moderna (MRNA) had not released enough information about its vaccine candidate to justify the optimism that had buoyed markets in recent days.


Luuuc
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PostPosted: 05/20/20 4:25 am    ::: Reply Reply with quote

tfan wrote:
Coronavirus: European stocks fall as doubts grow over vaccine


Quote:
A report from the highly respected Stat News suggested that Massachusetts-based Moderna (MRNA) had not released enough information about its vaccine candidate to justify the optimism that had buoyed markets in recent days.


Stock market investors are an impatient bunch



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tfan



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PostPosted: 07/18/20 1:42 am    ::: Reply Reply with quote

With coronavirus antibodies fading fast, vaccine hopes fade, too


Quote:
Disturbing new revelations that permanent immunity to the coronavirus may not be possible have jeopardized vaccine development and reinforced a decision by scientists at UCSF and affiliated laboratories to focus exclusively on treatments.


jammerbirdi



Joined: 23 Sep 2004
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PostPosted: 07/18/20 10:21 am    ::: Reply Reply with quote

tfan wrote:
With coronavirus antibodies fading fast, vaccine hopes fade, too


Quote:
Disturbing new revelations that permanent immunity to the coronavirus may not be possible have jeopardized vaccine development and reinforced a decision by scientists at UCSF and affiliated laboratories to focus exclusively on treatments.


Wow. That is a tough article. And the information runs very counter to everything we’ve been hearing these last few weeks.



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FrozenLVFan



Joined: 08 Jul 2014
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PostPosted: 07/18/20 7:56 pm    ::: Reply Reply with quote

I posted in some other thread that 3 pharma companies have had successful Phase 1 trials (small group of patients, designed to find optimum dose to produce antibodies without dire side effects) and plan to start Phase 3 trials later this month (thousands of patients to assess Ab production and longevity). Moderna is so confident their vax will work that they're already ramping up production of doses to distribute to the public.

So...like everything else with this novel disease, there are a lot of contradictions.


readyAIMfire53



Joined: 20 Nov 2004
Posts: 5819
Location: Durham, NC


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PostPosted: 07/18/20 11:40 pm    ::: Reply Reply with quote

tfan wrote:
With coronavirus antibodies fading fast, vaccine hopes fade, too


Quote:
Disturbing new revelations that permanent immunity to the coronavirus may not be possible have jeopardized vaccine development and reinforced a decision by scientists at UCSF and affiliated laboratories to focus exclusively on treatments.


And "herd immunity" for COVID is D.O.A. People have tested positive, then negative, then positive again. Either the antibodies they developed from initial infection failed to prevent reinfection or the virus was dormant inside was active, then dormant, then active again. And FYI, it has happened enough times, with multiple negative test and no symptoms until the next positive test that it is now confirmed in multiple cases in multiple countries.



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pilight



Joined: 23 Sep 2004
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PostPosted: 07/19/20 12:03 am    ::: Reply Reply with quote

readyAIMfire53 wrote:
tfan wrote:
With coronavirus antibodies fading fast, vaccine hopes fade, too


Quote:
Disturbing new revelations that permanent immunity to the coronavirus may not be possible have jeopardized vaccine development and reinforced a decision by scientists at UCSF and affiliated laboratories to focus exclusively on treatments.


And "herd immunity" for COVID is D.O.A. People have tested positive, then negative, then positive again. Either the antibodies they developed from initial infection failed to prevent reinfection or the virus was dormant inside was active, then dormant, then active again. And FYI, it has happened enough times, with multiple negative test and no symptoms until the next positive test that it is now confirmed in multiple cases in multiple countries.


It could be a problem with the test



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readyAIMfire53



Joined: 20 Nov 2004
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PostPosted: 07/19/20 9:57 pm    ::: Reply Reply with quote

pilight wrote:
readyAIMfire53 wrote:
tfan wrote:
With coronavirus antibodies fading fast, vaccine hopes fade, too


Quote:
Disturbing new revelations that permanent immunity to the coronavirus may not be possible have jeopardized vaccine development and reinforced a decision by scientists at UCSF and affiliated laboratories to focus exclusively on treatments.


And "herd immunity" for COVID is D.O.A. People have tested positive, then negative, then positive again. Either the antibodies they developed from initial infection failed to prevent reinfection or the virus was dormant inside was active, then dormant, then active again. And FYI, it has happened enough times, with multiple negative test and no symptoms until the next positive test that it is now confirmed in multiple cases in multiple countries.


It could be a problem with the test


I believe I was a false negative for COVID so that was my first thought. But it's happened so many times now that chances of so many test errors is shrinking. But you're right, I should list it as a possibility. Less likely than the two that I mentioned, but still possible.



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tfan



Joined: 31 May 2010
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PostPosted: 07/23/20 9:51 pm    ::: Reply Reply with quote

ON HOLD Bill Gates warns multiple coronavirus vaccine doses likely to be needed and schools should stay closed for another YEAR

Quote:

He said: "None of the vaccines at this point appear like they'll work with a single dose.

"That was the hope at the very beginning."


tfan



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PostPosted: 12/07/20 12:08 am    ::: Reply Reply with quote

Doctor and Johns Hopkins professor Marty Makary says that the FDA put an "unprecedented" month delay on the Phase III vaccine trial approval date, which put it beyond the election.

Quote:
Some sympathetic to the FDA career staff (*cough* great grandpa Fauci *cough*) have suggested that the U.K. was careless in approving the vaccine quickly, but the real story is how the American government bureaucracy wasted time.


And after Pfiizer submitted their data on November 22, the FDA scheduled their review meeting for December 12. Makary says the review, which is only a statistical analysis, can be done in 24 or 48 hours and that the review of manufacturing data should have started months ago.

Quote:
As a Johns Hopkins scientist who has conducted more than 100 clinical studies and reviewed thousands more from the scientific community at large, I can assure you that the agency’s review can be done within 24 to 48 hours without cutting any corners. They just need to work harder.


And then there is this "you can't make this up" issue from last January:

Quote:
Back in January, The Dispatch reported on the shocking story of how FDA regulators told University of Washington physician Dr. Alex Greninger that he could not test suspected COVID patients in Washington state, requiring him to first apply for an FDA authorization to do so. The complicated application Greninger completed sat at the FDA until he inquired about the delay. He was told that his electronically submitted application was incomplete because he had to also print it out and mail a physical copy along with a CD-ROM or hard drive of the electronic application.


https://thedispatch.com/p/fda-career-staff-are-delaying-the


readyAIMfire53



Joined: 20 Nov 2004
Posts: 5819
Location: Durham, NC


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PostPosted: 12/09/20 12:37 pm    ::: Reply Reply with quote

tfan wrote:


https://thedispatch.com/p/fda-career-staff-are-delaying-the


The Dispatch claims to print "the truth based on conservative principles." Translation: looking for any possible perceived slight to a conservative cause or candidate.

You can easily look at the history of FDA review of emergency authorizations and see that the "purposeful delay" is actually the FDA standard. MANY have objected through the years while loved ones waited for FDA authorization to receive life saving medications.

Long story short: the FDA did what the FDA always does and set the authorization date in their usual time frame. It had absolutely NOTHING to do with an election date. There was NO "delay."

We are sick of all the whiny babies who are looking for any and every excuse for why Trump lost. He lost because the great majority of people despise everything about him - 7 million more people than those who support him. People who despise everything about the man live all across the country, including in states where the majority of voters previously voted for him. They quite simply regret voting for him and voted against him at the next opportunity.

This is yet another weak attempt to not only excuse Trump's loss but to implicate Fauci in another false conspiracy theory. The sad thing is that some will believe it.



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FrozenLVFan



Joined: 08 Jul 2014
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PostPosted: 12/10/20 12:32 pm    ::: Reply Reply with quote

The FDA is a slow-moving bureaucracy just like every other agency in Washington. You don't have to look any further for reasons for their vaccine approval schedule.


GlennMacGrady



Joined: 03 Jan 2005
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PostPosted: 12/14/20 2:52 pm    ::: Reply Reply with quote

The speed with which the Covid vaccines have been developed has been remarkable, a testament to the positive powers of RNA science and a motivated federal government.

I hereby offer my ironclad, guaranteed, inevitable Covid vaccine predictions:

1. Everyone vaccinated will die.

2. The deaths will be very, very strongly correlated with the person's age at the time of vaccination.

3. The deaths will be most heavily concentrated in nursing homes. Unfortunately, some in nursing homes will die within a few days of being vaccinated.

The only thing I'm not sure about is how medical experts and the media will explain and headline these inevitable facts.
Howee



Joined: 27 Nov 2009
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PostPosted: 12/14/20 3:24 pm    ::: Reply Reply with quote

GlennMacGrady wrote:
I hereby offer my ironclad, guaranteed, inevitable Covid vaccine predictions:


Hmm. How 'guaranteed' is this prediction in comparison, say, to your "Covid Is An Overrated Hoax-y Thang?" predictions? Rolling Eyes



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tfan



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PostPosted: 12/15/20 2:34 am    ::: Reply Reply with quote

readyAIMfire53 wrote:
tfan wrote:


https://thedispatch.com/p/fda-career-staff-are-delaying-the


The Dispatch claims to print "the truth based on conservative principles." Translation: looking for any possible perceived slight to a conservative cause or candidate.


Seems like Trump caused the mainstream media too fully out themselves. They couldn't stop from showing their partisanship as well, even if they didn't put it into a summary line.

In this article a statement was made that they specifically added an extra month from their normal time period and that they said it was for safety. But we need a reference (not provided by the author) that shows that they have a standard time period to do whatever this was referred to as, and that in this instance it was extended by one month. Or alternatively, a reference that shows that this type of thing (time between trial end and application for vaccine approval?) has a history of wide variability in how long the FDA takes to do it. What I find is statements that the FDA has set two months for evaluation with nothing about the normal time limit. But two months sounds pretty quick when I have heard people say that it normally takes at least five plus years for a vaccine to come to market. So he probably did make that "added a month" up.

Quote:
THE FOOD AND DRUG Administration on Tuesday released new guidelines for coronavirus vaccine candidates that will likely push any regulatory approval for a vaccine beyond Election Day.

The nonbinding guidance recommends waiting a median duration of at least two months after trial participants receive their second dose before a company seeks an emergency use authorization for the vaccine.


tfan



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PostPosted: 01/11/21 9:07 pm    ::: Reply Reply with quote

Wall Street analysts are cautiously optimistic on J&J’s ‘one-dose’ Covid vaccine


Quote:
Johnson & Johnson is expected to deliver preliminary late-stage trial results for its one-dose Covid vaccine candidate by the end of January. If its jab is proven to be safe and effective, the company aims to deliver at least 1 billion doses by the end of the year.


tfan



Joined: 31 May 2010
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PostPosted: 01/12/21 9:54 pm    ::: Reply Reply with quote

Chinese Covid-19 Vaccine Far Less Effective Than Initially Touted in Brazil

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Results of Sinovac’s shot were almost 30 percentage points lower than previously announced, as concerns grow over study’s transparency

While Sinovac’s CoronaVac efficacy rate still meets the 50% threshold the World Health Organization considers good enough for widespread use, scientists said a lack of transparency about the data risks damaging the credibility of a vaccine Brazilians and others world-wide are already reluctant to take.

But after rising pressure from Brazilian scientists, some of whom accused the trial’s organizers of misleading the public, Butantan said Tuesday those rates only included volunteers who suffered mild to severe cases of Covid-19. When data from all volunteers was considered—including those who contracted “very mild” cases of Covid-19 and required no medical assistance—the total efficacy rate fell to 50.4%, Butantan said.


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